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Systemic lupus erythematosus (SLE) is an autoimmune disorder of unknown etiology. The disease is characterized by a great range of clinical manifestations, from mild with few symptoms to severe and life threatening. Systemic lupus erythematosus can affect any organ and every organ in the body, and is commonly seen in younger adults with a female predominance \[[@REF1]\]. Systemic lupus erythematosus is a very variable disease; some patients have mild disease and only an occasional flare while others have extensive disease with multiple organ involvement. The diagnostic criteria for SLE are clinical and immunological. Furthermore, laboratory findings should support a diagnosis of SLE. The clinical manifestations can be classified as cutaneous, mucocutaneous, musculoskeletal, neuropsychiatric, renal, cardiovascular or hematological \[[@REF1]\].
Renal manifestations are commonly seen in SLE and its prevalence ranges from 40% to 85% of cases. Nephritis is the most common renal involvement of SLE \[[@REF1]\]. In most cases, the renal lesions present as acute glomerulonephritis with the predominance of sub-epithelial immune complexes deposition (sub-EpIC) \[[@REF2]\]. It is more frequently seen in women than men, and women are twice more likely to have severe renal disease and end-stage renal disease (ESRD) \[[@REF1]\]. Renal biopsy is the gold standard for the diagnosis of lupus nephritis
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